Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction
Identifieur interne : 001605 ( Main/Exploration ); précédent : 001604; suivant : 001606Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction
Auteurs : Sandra Gelhaus [Allemagne] ; Bastian Thaa [Allemagne] ; Kathrin Eschke [Allemagne] ; Michael Veit [Allemagne] ; Christel Schwegmann-We Els [Allemagne]Source :
- Virology [ 0042-6822 ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Données de séquences moléculaires, Liaison aux protéines, Lignée cellulaire, Lipoylation, Maladies des porcs (virologie), Protéine S (), Protéine S (génétique), Protéine S (métabolisme), Protéines de la matrice virale (), Protéines de la matrice virale (génétique), Protéines de la matrice virale (métabolisme), Structure tertiaire des protéines, Suidae, Séquence d'acides aminés, Virion (), Virion (génétique), Virion (métabolisme), Virus de la gastroentérite transmissible (), Virus de la gastroentérite transmissible (génétique), Virus de la gastroentérite transmissible (métabolisme).
- MESH :
- génétique : Protéine S, Protéines de la matrice virale, Virion, Virus de la gastroentérite transmissible.
- métabolisme : Protéine S, Protéines de la matrice virale, Virion, Virus de la gastroentérite transmissible.
- virologie : Maladies des porcs.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Liaison aux protéines, Lignée cellulaire, Lipoylation, Protéine S, Protéines de la matrice virale, Structure tertiaire des protéines, Suidae, Séquence d'acides aminés, Virion, Virus de la gastroentérite transmissible.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Cell Line, Lipoylation, Molecular Sequence Data, Protein Binding, Protein S (chemistry), Protein S (genetics), Protein S (metabolism), Protein Structure, Tertiary, Sequence Alignment, Swine, Swine Diseases (virology), Transmissible gastroenteritis virus (chemistry), Transmissible gastroenteritis virus (genetics), Transmissible gastroenteritis virus (metabolism), Viral Matrix Proteins (chemistry), Viral Matrix Proteins (genetics), Viral Matrix Proteins (metabolism), Virion (chemistry), Virion (genetics), Virion (metabolism).
- MESH :
- chemical , chemistry : Protein S, Viral Matrix Proteins.
- chemical , genetics : Protein S, Viral Matrix Proteins.
- chemical , metabolism : Protein S, Viral Matrix Proteins.
- chemistry : Transmissible gastroenteritis virus, Virion.
- genetics : Transmissible gastroenteritis virus, Virion.
- metabolism : Transmissible gastroenteritis virus, Virion.
- virology : Swine Diseases.
- Amino Acid Sequence, Animals, Cell Line, Lipoylation, Molecular Sequence Data, Protein Binding, Protein Structure, Tertiary, Sequence Alignment, Swine.
Abstract
The spike protein S of coronaviruses contains a highly conserved cytoplasmic cysteine-rich motif adjacent to the transmembrane region. This motif is palmitoylated in the
Url:
DOI: 10.1016/j.virol.2014.07.035
PubMed: 25113909
PubMed Central: 7112097
Affiliations:
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Le document en format XML
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xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Thaa, Bastian" sort="Thaa, Bastian" uniqKey="Thaa B" first="Bastian" last="Thaa">Bastian Thaa</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Institute for Virology, Veterinary Faculty, Free University, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Veterinary Faculty, Free University, Robert-von-Ostertag-Str. 7-13, 14163 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eschke, Kathrin" sort="Eschke, Kathrin" uniqKey="Eschke K" first="Kathrin" last="Eschke">Kathrin Eschke</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Institute for Virology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559 Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Veit, Michael" sort="Veit, Michael" uniqKey="Veit M" first="Michael" last="Veit">Michael Veit</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Institute for Virology, Veterinary Faculty, Free University, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Veterinary Faculty, Free University, Robert-von-Ostertag-Str. 7-13, 14163 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Schwegmann We Els, Christel" sort="Schwegmann We Els, Christel" uniqKey="Schwegmann We Els C" first="Christel" last="Schwegmann-We Els">Christel Schwegmann-We Els</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Institute for Virology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559 Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line</term><term>Lipoylation</term><term>Molecular Sequence Data</term><term>Protein Binding</term><term>Protein S (chemistry)</term><term>Protein S (genetics)</term><term>Protein S (metabolism)</term><term>Protein Structure, Tertiary</term><term>Sequence Alignment</term><term>Swine</term><term>Swine Diseases (virology)</term><term>Transmissible gastroenteritis virus (chemistry)</term><term>Transmissible gastroenteritis virus (genetics)</term><term>Transmissible gastroenteritis virus (metabolism)</term><term>Viral Matrix Proteins (chemistry)</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Matrix Proteins (metabolism)</term><term>Virion (chemistry)</term><term>Virion (genetics)</term><term>Virion (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Lipoylation</term><term>Maladies des porcs (virologie)</term><term>Protéine S ()</term><term>Protéine S (génétique)</term><term>Protéine S (métabolisme)</term><term>Protéines de la matrice virale ()</term><term>Protéines de la matrice virale (génétique)</term><term>Protéines de la matrice virale (métabolisme)</term><term>Structure tertiaire des protéines</term><term>Suidae</term><term>Séquence d'acides aminés</term><term>Virion ()</term><term>Virion (génétique)</term><term>Virion (métabolisme)</term><term>Virus de la gastroentérite transmissible ()</term><term>Virus de la gastroentérite transmissible (génétique)</term><term>Virus de la gastroentérite transmissible (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Protein S</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein S</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein S</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Transmissible gastroenteritis virus</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Transmissible gastroenteritis virus</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéine S</term><term>Protéines de la matrice virale</term><term>Virion</term><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Transmissible gastroenteritis virus</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine S</term><term>Protéines de la matrice virale</term><term>Virion</term><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies des porcs</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Swine Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line</term><term>Lipoylation</term><term>Molecular Sequence Data</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term><term>Sequence Alignment</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Lipoylation</term><term>Protéine S</term><term>Protéines de la matrice virale</term><term>Structure tertiaire des protéines</term><term>Suidae</term><term>Séquence d'acides aminés</term><term>Virion</term><term>Virus de la gastroentérite transmissible</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The spike protein S of coronaviruses contains a highly conserved cytoplasmic cysteine-rich motif adjacent to the transmembrane region. This motif is palmitoylated in the <italic>Betacoronaviruses</italic> MHV and SARS-CoV. Here, we demonstrate by metabolic labeling with [<sup>3</sup>H]-palmitic acid that the S protein of transmissible gastroenteritis coronavirus (TGEV), an <italic>Alphacoronavirus</italic>, is palmitoylated as well. This is relevant for TGEV replication as virus growth was compromised by the general palmitoylation inhibitor 2-bromopalmitate. Mutation of individual cysteine clusters in the cysteine-rich motif of S revealed that all cysteines must be replaced to abolish acylation and incorporation of S into virus-like particles (VLP). Conversely, the interaction of S with the M protein, essential for VLP incorporation of S, was not impaired by lack of palmitoylation. Thus, palmitoylation of the S protein of <italic>Alphacoronaviruses</italic> is dispensable for S–M interaction, but required for the generation of progeny virions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abrami, L" uniqKey="Abrami L">L. Abrami</name></author><author><name sortKey="Kunz, B" uniqKey="Kunz B">B. Kunz</name></author><author><name sortKey="Iacovache, I" uniqKey="Iacovache I">I. Iacovache</name></author><author><name sortKey="Van Der Goot, F G" uniqKey="Van Der Goot F">F.G. van der Goot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrami, L" uniqKey="Abrami L">L. Abrami</name></author><author><name sortKey="Leppla, S H" uniqKey="Leppla S">S.H. Leppla</name></author><author><name sortKey="Van Der Goot, F G" uniqKey="Van Der Goot F">F.G. van der Goot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baudoux, P" uniqKey="Baudoux P">P. 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Lamb</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li><li>Berlin</li></region><settlement><li>Berlin</li><li>Hanovre</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Gelhaus, Sandra" sort="Gelhaus, Sandra" uniqKey="Gelhaus S" first="Sandra" last="Gelhaus">Sandra Gelhaus</name></region><name sortKey="Eschke, Kathrin" sort="Eschke, Kathrin" uniqKey="Eschke K" first="Kathrin" last="Eschke">Kathrin Eschke</name><name sortKey="Schwegmann We Els, Christel" sort="Schwegmann We Els, Christel" uniqKey="Schwegmann We Els C" first="Christel" last="Schwegmann-We Els">Christel Schwegmann-We Els</name><name sortKey="Thaa, Bastian" sort="Thaa, Bastian" uniqKey="Thaa B" first="Bastian" last="Thaa">Bastian Thaa</name><name sortKey="Veit, Michael" sort="Veit, Michael" uniqKey="Veit M" first="Michael" last="Veit">Michael Veit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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